Hubert Klumpner was born in Salzburg, Austria. He graduated in 1993 from the University of Applied Arts in Vienna in the Master Class of Prof. Hans Hollein. Klumpner worked with Enric Miralles and Paul Rudolph before receiving a Master of Science in Architecture and Urban Design from Columbia University in 1995. He has been a member of the German Chamber of Architects since 1997.

In 1998 he and Alfredo Brillembourg founded Urban-Think Tank (U-TT) in Caracas. Starting in 2007, Klumpner has been a guest professor at the Graduate School of Architecture and Planning, Columbia University, where he co-founded the Sustainable Living Urban Model Laboratory (S.L.U.M. Lab) with Alfredo Brillembourg. Along with Brillembourg, Klumpner holds the chair for Architecture and Urban Design at the Swiss Institute of Technology (Eidgenossische Technische Hochschule, ETH) in Zurich, Switzerland.

As co-principle of U-TT, Klumpner has received the 2010 Ralph Erskine Award, the 2011 Holcim Gold Award for Latin America, the 2012 Holcim Global Silver Award for innovative contributions to ecological and social design practices, and the 2012 Venice Biennale of Architecture Golden Lion.